![]() ![]() The possible value of ADAS-Cog expansion or reduction is less than compelling, particularly in MCI. The numerically largest SNRs were seen for the ADAS-Cog 5 in MCI and for both the 5- and 13-item ADAS-Cog variants in mild AD, although associated confidence intervals were large. ![]() SNRs were low in MCI but greater in mild AD. More than 90 % of subjects with mild AD had positive AD pathology. The annual decline in mild AD was more pronounced but still modest. The impact of enrichment was detectable but subtle in MCI. Approximately half of subjects with MCI fulfilled enrichment criteria for positive AD pathology. The decline over time on any of the ADAS-Cog variants was minimal in subjects with MCI. Direct cross-comparison of the ADAS-Cog variants was performed using the signal-to-noise ratio (SNR), with higher values reflecting increased sensitivity to detect change over time. The decline over time was defined by change from baseline. Subjects with mild cognitive impairment (MCI) and mild AD with available ADAS-Cog 13 and CSF data were analysed. Given the interest in enrichment strategies, we also examined this aspect with a focus on cerebrospinal fluid (CSF) markers. Using Alzheimer’s Disease Neuroimaging Initiative data, we compared the performance of the 3-, 5-, 11- and 13-item ADAS-Cog variants in subjects with early AD. Attempts to improve its properties for early AD by removing items prone to ceiling and/or by adding cognitive measures known to be impaired early have yielded a number of ADAS-Cog variants. The 11-item version of the Alzheimer’s Disease Assessment Scale–Cognitive subscale (ADAS-Cog) was originally developed to measure cognition in patients with mild to moderate AD. Development of new treatments for Alzheimer’s disease (AD) has broadened into early interventions in individuals with modest cognitive impairment and a slow decline. ![]()
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